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Product Description

Pharmaceutical Mirabegron Material Mirabegron powder Mirabegron

Product Description

 

 

 

 

 

Product CZPT ls

 

 

 

Product Name Mirabegron  
CAS 223673-61-8
Appearance White crystalline powder
MF 223673-61-8
MW C21H24N4O2S
Purity 99%
Shelf Life 2 Years

Miraberone is the first beta-3 adrenergic agonist in the treatment of overactive bladder, and its successful marketing fills the gap in the treatment of overactive bladder with beta-3 adrenergic agonist.
 

Application&Function

 

 

 

Mirabegron was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting anilines is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
 

Specification