Manufacturer supplier Supply 99% Bulk CAS 223673-61-8 Mirabegron with ce certificate top quality low price

Product Description

 

Product name Mirabegron
CAS 223673-61-8
Appearance white powder
Assay 99%
Storage Cool and Protect from light

Product Name:Mirabegron
CAS:223673-61-8
MF:C21H24N4O2S
MW:396.506
EINECS:800-126-3
Mol File:223673-61-8.mol  
Melting point:138-140°C
Boiling point:690.0±55.0 °C(Predicted)
Density 1.313
storage temp. -20°C CZPT r
pka13.51±0.70(Predicted)

Description
etanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting anilines is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
Chemical PropertiesWhite to Off-White Solid
OriginatorAstellas Pharma Inc. (Japan)
UsesMirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
UsesA potent bladder relaxant compound
UsesPotent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

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