High Cost Purity Best Price Mirabegron Pharmaceutical Intermediate with CAS 223673-61-8 Mirabegron Powder with ce certificate top quality low price

Product Description

High CZPT Best Price Mirabegron with CAS 223673-61-8 Mirabegron Powder

Product Description


What is Mirabegron?

Mirabegron is for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.

Function and Application 

1.Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
2.Uses for A potent bladder relaxant compound
3.Uses for Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

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Q1:Can you give me a discount price?

A1:Sure, it depends on your quantity.

Q2: What about the lead time? 

A2:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity.

Q3:How do you control the quality? 

A3:We will make samples before mass production, and after sample approved, we will begin bulk production.

Q4:How do you ship the goods and how CZPT does it take to arrive? 

A4:We usually ship by UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.

Q5:What is you terms of payment?

A5:Our normal payment term is T/T 30% deposit after order signed and 70% before shippment.

Q6:Is there cheap shipping cost to import to CZPT country? 

A6:For small order, express will be best. And for bulk order, sea ship way is best but take much time.