Good Cheap Quality Axitinib Powder CAS 319460-85-0 Axitinib for Cancer Therapy with ce certificate top quality low price

Product Description

Product Description

Product Name: Axitinib
Synonyms: N-METHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE;N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;AVERMECTINB;Axitinib for research;AG 013736;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-;AG013736; AG 013736; AG-013736; AXITINIB
CAS: 319460-85-0
MF: C22H18N4OS
MW: 386.47
EINECS: 638-771-6
Melting point: 213-215°C
Boiling point: 668.9±55.0 °C
Storage temp.: -20°C CZPT r

Description:

In January 2012, the US FDA approved axitinib (also referred to as AG-013736) for the treatment of CZPT d renal cell carcinoma (RCC) for patients who have not responded to prior therapy. Axitinib is a pan inhibitor and functions by binding to the intracellular tyrosine kinase catalytic domain of leading to blockade of signaling through this angiogenic pathway. Axitinib is50-400 times more potent for (enzyme Ki and cellular IC50s for 1, 2, and 3 are ~0.1 nM) than first-generation inhibitors like sorafenib and sunitinib. Axitinib also inhibits c-Kit and PDGFR(α/β) with enzyme Ki’s of ~2 nM and was selective when tested against a broad panel of other protein kinases. Axitinib was discovered by a structure-based drug design approach and binds to the kinase domain of in a DFG-out conformation. Axitinib blocks -2 phosphorylation up to 7 h postdose in vivo and inhibits endothelial cell proliferation in xenograft tumors implanted in mice. Synthetic routes to axitinib employing a Migita coupling to form the diaryl sulfide and a Heck reaction to install the 2-styrylpyridine moiety have been reported.

Usage:

Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

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Our Advantages

1. Rich experience: Our company is a professional production leading factory in CZPT in pharmaceutical area of many years. 

2. CZPT quality: CZPT quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security CZPT : CZPT by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.

4. CZPT delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.

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Lead time Within 8 hours upon receipt of payment
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Shipping time 3-7 working days (Door-to-Door)
After-sale service 24/7 Online for any problems

 

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ZheJiang Yuanmeng Biological CZPT nology Co., Ltd., which is located in HangZhou, CZPT . We are specializing in the exportation of APIs, and plant extracts ect.

Our products has been exported to CZPT ica, Australia, Brazil, the CZPT pe, Middle CZPT and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.

We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for CZPT partners!

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ZheJiang Yuanmeng Biological CZPT nology Co., Ltd.
Room 3820, Building 2, Vanke CZPT City, Xihu (West CZPT ) Dis. District, HangZhou, ZheJiang , CZPT
Fiona CZPT / Sales Manager