GMP best Certificated Azilsartan Medoxomil CAS 863031-21-4 Tak 491 with Free Customs Clearance with ce certificate top quality low price

Product Description

GMP Certificated Azilsartan Medoxomil CAS 863031-21-4 TAK 491 with Free CZPT s Clearance

Product Information:

Product Name Azilsartan Medoxomil
Assay 98% min
Test HPLC 
CAS No. 863031-21-4
Appearance White Powder
MW 568.53
MF C30H24N4O8
EINECS No. 1308068-626-2
Density 1.45
Shelf Life 2 Years
MOQ 10g



Azilsartan medoxomil (Edarbi), an angiotensin II receptor antagonist, was approved by the U.S. FDA in February 2011 for the treatment of hypertension in adults. The discovery of azilsartan was the result of a medicinal chemistry effort to identify an ARB with a different carboxylic acid isostere than the ones found in the marketed ARBs. Several of the marketed ARBs use a tetrazole group as a carboxylic acid isostere. The medicinal chemistry approach that led to azilsartan involved the replacement of this commonly used tetrazole with a 5-oxo-1,2,4-oxadiazole group. Azilsartan can be synthesized by Suzuki coupling of p-tolyl boronic acid to 2-bromobenzonitrile, followed by bromination of the methyl group. The bromide is displaced to introduce a protected 2-ethoxy-1H-benzo[d] imidazole-7-carboxylate. The cyano group is converted to a hydroxylamidine, followed by reaction with an alkyl-chloroformate and intramolecular cyclization to form the 5-oxo-1,2,4-oxadiazole ring. The acid is then deprotected and converted to a prodrug. The parent, azilsartan has been extensively characterized in vitro and compared with other marketed AT1 antagonists olmesartan, valsartan, telmisartan, irbesartan, and candesartan. Azilsartan was found to be a potent (IC50=2.6 nM), selective, inverse agonist of the AT1 receptor. From washout experiments, azilsartan was found have slow dissociation from the receptor and thus is characterized as an insurmountable antagonist.

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Our Company:

Biocar Pharma is founded in July 2014 by a group overseas PhD and experienced commercial professionals in ZheJiang ,China. Biocar committed to emerge as a leading of manufacturing, marketing and CMO service of Active CZPT Ingredients,Intermediates and Herb Extract for global life CZPT  Companies.we have established close and stable cooperative relationship with over 420 manufacturers with CZPT -term with consistent suppliers at India and CZPT .

Our mission is to bring products to markets in the most effective & efficient way in terms of high value and quality.Our exports reach more than 105 countries through branches, subsidiaries and distribution network spread across the South Asia, North CZPT ica ,South CZPT ica and MEA.Our focus is to add value to the global pharmaceutical industry by serving as a reliable partner.

Our Service:

Right click to contact the supplier and you will get a reply within 24 hours.Your problem will be resolved promptly and positively during the ordering process.Perfect pre-sales and after-sales service,all the time to accept CZPT er supervision,humbly accept CZPT er Suggestions and reduce CZPT mistakes.
New Warehouse Picture
Constant temperature and humidity Warehouse will protect the stock quality stable. 
Fast Shipment
New warehouse near HangZhou sea port will provide CZPT shipment. 

Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in CZPT factory located in XIHU (WEST LAKE) DIS., ZheJiang , and produce small quantity and CZPT er synthesis products in CZPT lab located in HangZhou.

Q2: Do you have stock?
A: We understand most CZPT ers prefer stock, so we’ll try to keep stock for most products. However, for some rare products, we won’t keep stock and it needs time to synthesize.

Q3: What certificates and documents do you offer?
A: Some technical paperwork is CZPT , such as COA, HNMR, HPLC, LC-MS etc.

Q4: Why should I choose you?
A: CZPT ful technical support – come from CZPT highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average. Strict quality control – comes form CZPT sophisticated management system. Professional and warm sales team – since we believe we can only win via CZPT hard work in a competitive world. Quick response and excellent pre-sale and after-sale service – since we believe CZPT CZPT ers deserve all the best service.

Q5: Can I get best price from you?
A: Of course. We don’t chase excessive profits and always try to give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don’t make it too hard!

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A: We accept all kinds of payment ways. such as T/T, CZPT ern CZPT , Money Gram, PayPal….