Efficient supplier Spot Raw Material Drug Mirabegron Bladder Contraction Inhibitor with ce certificate top quality low price

Product Description

Efficient spot raw material drug Mirabegron bladder contraction inhibitor

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Product Name:Mirabegron
CAS:223673-61-8
MF:C21H24N4O2S
MW:396.506
EINECS:800-126-3
Mol File:223673-61-8.mol  
Melting point:138-140°C
Boiling point:690.0±55.0 °C(Predicted)
Density 1.313
storage temp. -20°C CZPT r
pka13.51±0.70(Predicted)

Description:
etanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting anilines is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
Chemical PropertiesWhite to Off-White Solid
OriginatorAstellas Pharma Inc. (Japan)

Function:
UsesMirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
UsesA potent bladder relaxant compound
UsesPotent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

Our Company:

Biocar Pharma is founded in July 2014 by a group overseas PhD and experienced commercial professionals in ZheJiang ,China. Biocar committed to emerge as a leading of manufacturing, marketing and CMO service of Active CZPT Ingredients,Intermediates and Herb Extract for global life CZPT Companies.we have established close and stable cooperative relationship with over 420 manufacturers with CZPT -term with consistent suppliers at India and CZPT .Our mission is to bring products to markets in the most effective & efficient way in terms of high value and quality.Our exports reach more than 105 countries through branches, subsidiaries and distribution network spread across the South Asia, North CZPT ica ,South CZPT ica and MEA.Our focus is to add value to the global pharmaceutical industry by serving as a reliable partner.

Our Main Product:

Our Advantage:

1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2. Quality: Our company is a professional leading factory in CZPT in pharmaceutical area, We had stable CZPT ers and exported to Germany, Spain, UK, USA, Australia, Middle CZPT , and any other countries. We can provide good references about CZPT company. As for the quality of the products, we ‘re sure they can satisfy you well enough;
3. Package: Professional packing with professional materials
4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
5. Service: Best Service with after-sales service and consultation

Feedback
1. Professional service and rich experience make CZPT ers feel at ease, adequate stock and CZPT delivery meet their desire.
2. Market feedback and goods feedback will be appreciated , meeting CZPT ers’ requirement is CZPT responsibility.
3. CZPT quality, competitive price, CZPT delivery, first-class service gain the CZPT and praise from the CZPT ers.
5.Sample order are welcome.
6.NMR,HPLC and COA can be supplied
7.We can supply sample for testing
8.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!

 

Our Advantages / The 7 reasons are as below:
  1 Rich experience Our company is a professional leading supplier in pharmaceutical and chemical area for many years.
  2 Suitable packagings The packing suits you best would be choosen to cross CZPT s safely. Or if you have your own ideal way, it CZPT also taken in consideration
  3 High quality High quality guaranteed, product is tested before shipment.
  4 Secure shipping Shipping by professional forwarder Security EMS/DHL/TNT/FedEx/UPS,AusPost,
CZPT Mail express,etc.Door to door service.
  5 Fast delivery We have stock, so we can deliver quickly once payment isreceived.
  6 Quality service Warm aftersale service is supplied,if any question we 
will reply you within 8 hours.
  7 Competitive prices A discount would be given when you make a large order. VIP price for next orders.

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Contact:
Telephone: -571-87057105
Mobile:   -13397193525
Online Store: http://biocar.en.made-in-china.com/
©HangZhou Newbio Pharm-Tech Co., Ltd.
Biocar is a reliable supplier and looks for a long term business relationship!!!