Common near me shop Human Diseases Gastrointestinal Bladder Raw Materials Mirabegron CAS 223673-61-8 with ce certificate top quality low price

Product Description

Common Xihu (West CZPT ) Dis.n Diseases Gastrointestinal Bladder Raw CZPT Mirabegron CAS 223673-61-8

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Product Name:Mirabegron
Mol File:223673-61-8.mol  
Melting point:138-140°C
Boiling point:690.0±55.0 °C(Predicted)
Density 1.313
storage temp. -20°C CZPT r

etanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting anilines is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
Chemical PropertiesWhite to Off-White Solid
OriginatorAstellas Pharma Inc. (Japan)

UsesMirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
UsesA potent bladder relaxant compound
UsesPotent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

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Biocar Pharma is founded in July 2014 by a group overseas PhD and experienced commercial professionals in ZheJiang ,China. Biocar committed to emerge as a leading of manufacturing, marketing and CMO service of Active CZPT Ingredients,Intermediates and Herb Extract for global life CZPT Companies.we have established close and stable cooperative relationship with over 420 manufacturers with CZPT -term with consistent suppliers at India and CZPT .Our mission is to bring products to markets in the most effective & efficient way in terms of high value and quality.Our exports reach more than 105 countries through branches, subsidiaries and distribution network spread across the South Asia, North CZPT ica ,South CZPT ica and MEA.Our focus is to add value to the global pharmaceutical industry by serving as a reliable partner.

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